College of Agricultural Sciences

G. R. Garcia, Bugel, S. M., Truong, L., Spagnoli, S., and Tanguay, R. L., “AHR2 required for normal behavioral responses and proper development of the skeletal and reproductive systems in zebrafish.”, PLoS One, vol. 13, no. 3, p. e0193484, 2018.

A. K. Ehrlich, Pennington, J. M., Tilton, S., Wang, X., Marshall, N. B., Rohlman, D., Funatake, C., Punj, S., O'Donnell, E. F., Yu, Z., Kolluri, S., and Kerkvliet, N. I., “AhR activation increases IL-2 production by alloreactive CD4 T cells initiating the differentiation of mucosal-homing Tim3 Lag3 Tr1 cells.”, Eur J Immunol, vol. 47, no. 11, pp. 1989-2001, 2017.

E. F. O'Donnell, Jang, H. Sang, Pearce, M. C., Kerkvliet, N. I., and Kolluri, S., “The aryl hydrocarbon receptor is required for induction of p21cip1/waf1 expression and growth inhibition by SU5416 in hepatoma cells.”, Oncotarget, vol. 8, no. 15, pp. 25211-25225, 2017.

G. R. Garcia, Goodale, B. C., Wiley, M. W., La Du, J. K., Hendrix, D. A., and Tanguay, R. L., “In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression.”, Mol Pharmacol, vol. 91, no. 6, pp. 609-619, 2017.

S. Kolluri, Jin, U. - H., and Safe, S., “Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.”, Arch Toxicol, vol. 91, no. 7, pp. 2497-2513, 2017.

A. K. Ehrlich, Pennington, J. M., Wang, X., Rohlman, D., Punj, S., Löhr, C. V., Newman, M. T., Kolluri, S., and Kerkvliet, N. I., “Activation of the Aryl Hydrocarbon Receptor by 10-Cl-BBQ Prevents Insulitis and Effector T Cell Development Independently of Foxp3+ Regulatory T Cells in Nonobese Diabetic Mice.”, J Immunol, vol. 196, no. 1, pp. 264-73, 2016.

B. C. Goodale, La Du, J., Tilton, S. C., Sullivan, C. M., Bisson, W. H., Waters, K. M., and Tanguay, R. L., “Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs.”, Toxicol Sci, vol. 147, no. 2, pp. 397-411, 2015.

S. Punj, Kopparapu, P., Jang, H. Sang, Phillips, J. Lynne, Pennington, J. M., Rohlman, D., O'Donnell, E. F., Iversen, P. L., Kolluri, S., and Kerkvliet, N. I., “Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease.”, PLoS One, vol. 9, no. 2, p. e88726, 2014.

C. V. Gerlach, Das, S. R., Volz, D. C., Bisson, W. H., Kolluri, S. K., and Tanguay, R. L., “Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish.”, Aquat Toxicol, vol. 154, pp. 71-9, 2014.

B. C. Goodale, La Du, J. K., Bisson, W. H., Janszen, D. B., Waters, K. M., and Tanguay, R. L., “AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish.”, PLoS One, vol. 7, no. 1, p. e29346, 2012.

E. F. O'Donnell, Kopparapu, P. Rao, Koch, D. C., Jang, H. Sang, Phillips, J. Lynne, Tanguay, R. L., Kerkvliet, N. I., and Kolluri, S. Kumar, “The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells.”, PLoS One, vol. 7, no. 7, p. e40926, 2012.

E. F. O'Donnell, Saili, K. S., Koch, D. C., Kopparapu, P. R., Farrer, D., Bisson, W. H., Mathew, L. K., Sengupta, S., Kerkvliet, N. I., Tanguay, R. L., and Kolluri, S. Kumar, “The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor.”, PLoS One, vol. 5, no. 10, 2010.

L. K. Mathew, Simonich, M. T., and Tanguay, R. L., “AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration.”, Biochem Pharmacol, vol. 77, no. 4, pp. 498-507, 2009.

W. H. Bisson, Koch, D. C., O'Donnell, E. F., Khalil, S. M., Kerkvliet, N. I., Tanguay, R. L., Abagyan, R., and Kolluri, S. Kumar, “Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands.”, J Med Chem, vol. 52, no. 18, pp. 5635-41, 2009.

L. K. Mathew, Sengupta, S. S., LaDu, J., Andreasen, E. A., and Tanguay, R. L., “Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish.”, FASEB J, vol. 22, no. 8, pp. 3087-96, 2008.

B. R. Evans, Karchner, S. I., Allan, L. L., Pollenz, R. S., Tanguay, R. L., Jenny, M. J., Sherr, D. H., and Hahn, M. E., “Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator.”, Mol Pharmacol, vol. 73, no. 2, pp. 387-98, 2008.

E. A. Andreasen, Mathew, L. K., Löhr, C. V., Hasson, R., and Tanguay, R. L., “Aryl hydrocarbon receptor activation impairs extracellular matrix remodeling during zebra fish fin regeneration.”, Toxicol Sci, vol. 95, no. 1, pp. 215-26, 2007.

L. K. Mathew, Andreasen, E. A., and Tanguay, R. L., “Aryl hydrocarbon receptor activation inhibits regenerative growth.”, Mol Pharmacol, vol. 69, no. 1, pp. 257-65, 2006.

A. L. Prasch, Tanguay, R. L., Mehta, V., Heideman, W., and Peterson, R. E., “Identification of zebrafish ARNT1 homologs: 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the developing zebrafish requires ARNT1.”, Mol Pharmacol, vol. 69, no. 3, pp. 776-87, 2006.

C. J. Funatake, Marshall, N. B., Steppan, L. B., Mourich, D. V., and Kerkvliet, N. I., “Cutting edge: activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+ CD25+ cells with characteristics of regulatory T cells.”, J Immunol, vol. 175, no. 7, pp. 4184-8, 2005.

C. Weiss, Faust, D., Dürk, H., Kolluri, S., Pelzer, A., Schneider, S., Dietrich, C., Oesch, F., and Göttlicher, M., “TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.”, Oncogene, vol. 24, no. 31, pp. 4975-83, 2005.

J. M. Zodrow, Stegeman, J. J., and Tanguay, R. L., “Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish.”, Aquat Toxicol, vol. 66, no. 1, pp. 25-38, 2004.

J. M. Zodrow and Tanguay, R. L., “2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits zebrafish caudal fin regeneration.”, Toxicol Sci, vol. 76, no. 1, pp. 151-61, 2003.

E. A. Andreasen, Tanguay, R. L., Peterson, R. E., and Heideman, W., “Identification of a critical amino acid in the aryl hydrocarbon receptor.”, J Biol Chem, vol. 277, no. 15, pp. 13210-8, 2002.

E. A. Andreasen, Spitsbergen, J. M., Tanguay, R. L., Stegeman, J. J., Heideman, W., and Peterson, R. E., “Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.”, Toxicol Sci, vol. 68, no. 2, pp. 403-19, 2002.